Breaking Down the Myths Surrounding Unexplained Infertility
Myths surrounding reproductive health and fertility bring confusion and missed chances for specialized care. Incorrect information about unexplained infertility impacts how people plan their families and may contribute to challenges in giving birth. Understanding the facts around these myths may help couples navigate the fertility journey and acquire appropriate treatment plans. Here are some common myths surrounding unexplained infertility:
What Is Unexplained Infertility?
Unexplained infertility is the term used when no cause of infertility is found after routine tests, including semen analysis, ovulation monitoring, and imaging tests, have been performed. Often, endometrial inflammation affects the implantation. This inflammation can be detected by testing the biomarker BCL6 in the uterine lining, even in the absence of visible symptoms. Some women with unexplained infertility have elevated levels of BCL6, which indicates a high prevalence of inflammation. Accurate testing helps differentiate between cases with and without inflammation. Tests also provide clarity and direction for the next course of action. Having a diagnosis may help doctors develop a clear treatment plan.
Implantation Failure Beyond Embryo Quality
Most couples believe that the unsuccessful embryo transfers are due to the quality of the embryo or the wrong timing. In practice, implantation can be affected by chronic uterine inflammation, even in the case of high-quality and time-appropriate embryos. The endometrial test detects markers for progesterone resistance and endometritis that are not measured by standard embryo assessment tools. High levels of BCL6 are associated with low implantation success, even when the embryos are of optimal quality. Proper diagnosis changes the course of clinical management for repeated IVF to treatment of inflammation. Such a reorientation can avoid unnecessary procedures and enhance better outcomes.
Prevalence of Silent Endometriosis
Asymptomatic endometriosis, also known as silent endometriosis, can be present even when there is no pain or menstrual irregularities. The inflammation of the endometrium associated with this condition may lead to the inability to implant an embryo, but it is not identified when symptomatic assessment is used. Advanced testing allows the detection of this inflammation through a tissue biopsy of the uterine lining. High levels of BCL6 indicate inflammation in situations where the patient experiences no discomfort. Some women who have had repeated implantation failure or loss of pregnancy have positive results for inflammation of the endometrium. Proper diagnosis facilitates medical judgments and individualized treatment.
The Value of Early Diagnosis Before IVF
It is a myth that inflammation will always have symptoms. In some cases, markers of endometrial inflammation or bacterial infection can be detected without pelvic pain or bleeding. The testing regimen involves the detection of CD138, a marker of chronic endometritis, and BCL6. The results showing the presence of CD138 demonstrate the presence of bacterial inflammation in patients who exhibit no characteristic manifestations. Further testing is useful even in cases where fertility experts observe no backward indicators. Patients with positive results are provided with access to targeted treatment.
Some practitioners do not test inflammation until after numerous unsuccessful assisted reproductive procedures. When testing occurs at the beginning or before the IVF process, it can prevent unnecessary cycles due to inflammation. Identifying BCL6 and CD138 markers before transferring the embryos enables clinicians to treat inflammation and improve the implantation conditions before executing IVF. Early treatment based on test results directs fertility treatment on a personalized approach. This method aligns with the clinical goal of transitioning patients from symptom-driven management to evidence-based practices.
Effective Treatment Options
Endometrial inflammation or chronic infection can be effectively treated using evidence-based therapies once it is detected. Hormone therapy helps eliminate inflammatory processes associated with progesterone resistance. In the confirmed cases of endometriosis, surgical treatment may eliminate lesions that interfere with the receptivity of the uterus. In case of bacterial infection, antibiotic treatment is effective against CD138-positive endometritis. Combined treatments lower inflammation and increase the chances of implantation, helping to improve fertility. These treatments change the unexplained infertility into a condition that can be handled.
Explore the Truth About Unexplained Infertility
The ability to detect inflammation—often without noticeable symptoms—before undergoing extensive IVF procedures empowers patients and clinicians to take targeted action. Health and fitness play a crucial role in supporting fertility, as underlying issues like hormone resistance, endometriosis, or uterine infections can often be linked to lifestyle and overall well-being. With accurate testing, patients can make informed decisions, improve clinical outcomes, and increase their chances of successful conception. Maintaining a balanced fitness routine and addressing health markers early on can significantly enhance fertility outcomes. Always consult a trusted reproductive specialist to better understand unexplained infertility and develop the right treatment plan.
